Who am I?
I'm a physicist by training (Technical University of
Munich), and have since done a PhD in Bioinformatics at the University of Cambridge with the
European Bioinformatics Institute (EBI), an
outstation of the European Molecular Biology Laboratory (EMBL). While I have recently moved labs,
I still regularly go there to see collaborators and friends.
I collaborate with David MacKay in the Cavendish Laboratory's Inference Group on
the application and development of Independent Component Analysis to
RNA Expression Profiles from Microarrays. My base in biology is the
Genetics Department, where I
work in Gos Micklem's group (Ashburner lab)
as a Research Fellow of the Medical Research Council (MRC). I have introduced novel
processes at their FlyChip
Microarray facility, with the aim of a calibrated configuration
suitable for truly quantitative work. In the long term I am, however,
mostly interested in taking the analysis further, extending previous
work by David MacKay and James Miskin, and applying it to specific
biological problems of interest. It is likely that we will be
employing John Winn's latest VIBES platform.
Contact
The best way to contact me is by e-mail to D.Kreil at
gen.cam.ac.uk.
Please feel free to use my PGP public
key.
If you prefer to talk, please leave a message on +44 (0)1223 / 858
665, and I will return your call. This number is also active when I am
not in the UK.
You will also often find me in Darwin College, of which I am a
Research Fellow. Selvino De Kort and I organize the Sciences
Group seminars. If you are with Darwin and are interested in
giving a talk, please get in touch.
I have now accepted a call to
Vienna, where I am
starting a new group as Chair of
Bioinformatics. I am still in Cambridge every few months to see
friends and collaborators, so, if you don't want to travel to Vienna
(but you do) then we can usually also arrange to meet in Cambridge.
The Darwin Sciences Group seminars are now organized by Ellen Nisbet
(rern2 at mole.bio.cam.ac.uk).
Meeting Invitation
We are organizing an Intl. Workshop on
Probabilistic Modelling in Computational Biology
in affiliation with ISMB/ECCB 2007 in Vienna this year and much look
forward to seeing you there!
Publications
Note that this list is not updated anymore, and is only maintained for
reference. Please visit our new group pages.
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file formats used.
Recent work with the Inference Group
- D. P. Kreil and D. J. C. MacKay, Reproducibility Assessment of
Independent Component Analysis of Expression Ratios from DNA
microarrays
- S. A. Saidi, C. M. Holland, D. P. Kreil, D. J. C. MacKay,
D. S. Charnock-Jones, C. G. Print, and S. K. Smith,
Independent Component Analysis of Microarray Data in the Study
of Endometrial Cancer
Other papers
- D. P. Kreil and R. R. Russell, There is no silver
bullet – a guide to low-level data transforms and
normalisation methods for microarray data
- A. Woolfson, J. Stebbing, B. Tom, K. Stoner, W. Gilks,
D. P. Kreil, S. Mulligan, L. Belov, J. Chrisp,
W. Errington, A. Wildfire, W. Erber, M. Bower, B. Gazzard,
R. Christopherson, and M. Scott, Conservation of unique
cell surface CD antigen mosaics in HIV-1 infected
individuals
- Published in print by Blood (2005), in press.
- Preprint [coming soon]
- R. P. Auburn, D. P. Kreil, L. A. Meadows, B. Fischer,
S. Sevillano Matilla, and S. Russell, Robotic
spotting of cDNA and oligonucleotide microarrays
- Published in print by Trends in Biotechnology
(2005), in press.
- Preprint
[132kB pdf]
- Supplement
[49kB pdf]
- D. P. Kreil, N. A. Karp, and K. S. Lilley (2004), DNA microarray
normalization methods can remove bias from differential protein
expression calls in 2-D difference gel electrophoresis
- N. A. Karp, D. P. Kreil, and K. S. Lilley (2004)
Determining a significant change in protein expression with
DeCyder for pair-wise comparisons using 2-D difference gel
electrophoresis
- T. Kanno, M. F. Mette, D. P. Kreil, W. Aufsatz, M. Matzke,
and A. J. Matzke, Involvement of Putative SNF2 Chromatin
Remodeling Protein DRD1 in RNA-Directed DNA Methylation
- D. P. Kreil and C. A. Ouzounis, Comparison of sequence
masking algorithms and the detection of biased protein sequence
regions
- D. P. Kreil and C. A. Ouzounis (2001), Identification of
thermophilic species by the amino acid compositions deduced from
their genomes, Nucleic
Acids Research 29(7),
1608-1615.
(free reprint / full text access)
- D. P. Kreil and G. Kreil (2000), Asparagine repeats are rare
in mammalian proteins,
Trends Biochem. Sciences
25(6), 270-271.
(reprint via
ScienceDirect, or drop
me a line)
- V. J. Promponas, A. J. Enright, S. Tsoka, D. P. Kreil,
C. Leroy, S. Hamodrakas, C. Sander, and C. A. Ouzounis (2000),
CAST: an iterative algorithm for the Complexity
Analysis of Sequence Tracts,
Bioinformatics 16(10),
915-922.
(free reprint / full text access)
- D. P. Kreil and T. Etzold (1999), DATABANKS - a
catalogue database of molecular biological databanks,
Trends Biochem. Sciences
24(4), 155-157.
(reprint via
ScienceDirect, or drop
me a line)
Books
- M. Matzke, T. Kanno, B. Hüttel, E. Jaligot, M. F. Mette,
D. P. Kreil, L. Daxinger, P. Rovina, W. Aufsatz, and
A. J. M. Matzke (2005), RNA-directed DNA methylation in